EU regulators have prioritized Clean nails by classifying TPO as a CMR 1B substance, meaning it may be carcinogenic, mutagenic, or harmful to reproduction. Previously capped at 5% in topcoat nail applications, it’s now prohibited entirely under the Omnibus VII update. So if you’re not rocking the Clean Girl Manicure Trend, keep reading.
This guide is part of our Nail Care & Clean Polish collection. For more ideas, see Nail Art & Design: The Complete Guide.
On September 1, 2025, the European Union enacted a sweeping ban on trimethylbenzoyl diphenylphosphine oxide (TPO), a key ingredient commonly found in many topcoat nail products. This chemical, known as a photo initiator, helps topcoat nail formulas cure quickly under UV or LED light while delivering that coveted ultra-glossy finish.
Why the EU Said “No” to TPO
The decision stems from animal studies suggesting health risks, especially concerning reproductive toxicity. While human evidence is not definitive, the EU’s precautionary principle, a hallmark of its cosmetics regulation, drove the full ban.
Immediate Impact: Who Is Affected?
- Salon pros and salons across the EU must immediately stop using, selling, or distributing any TPO-containing products. There is no grace period to sell through old stock.
- Manufacturers and distributors must reformulate all products distributed in Europe or face fines and penalties.
- Consumers may notice fewer gel options in Europe unless brands have switched to TPO-free formulas.
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Brands That Already Said Goodbye to TPO
Manucurist has been ahead of the curve, using TPO L, a safer non-CMR photoinitiator, in its Green Flash™ line. Features include 84 percent bio-sourced ingredients, vegan formulas, and up to 12-day wear.
Similarly, Elegelli announced all its gel products are TPO-free, meeting EU regulations without compromising performance. Other known TPO-free alternatives include:
- OPI’s Intelli Gel system
- Aprés Nail
- Nail Creation
- Aimeili
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The U.S. Contrast: Business as Usual for Now
Unlike the EU, the United States has not banned TPO. Gel nail salons in the U.S. continue using TPO-based products, although some may voluntarily switch as formulations shift globally.
Smart Moves for Mani Lovers
- Ask salons if they use TPO-free products, especially if you are cautious about potential risks.
- Space out your gel manicures, use a fortifying base coat, and ensure good ventilation during application.
- Watch out for other risks, such as UV exposure and nail infections like Pseudomonas associated with lifted gels.
Signing Off with a Glossy but Safe Finish
The EU’s TPO ban marks a bold leap in cosmetic safety, even if based largely on precaution. If you are in Europe, prepare for a shift in nail salon menus. And if you are elsewhere, this regulatory move might still inspire safer formulations worldwide.
Stay glossy, stay safe!
What is a top coat for nails?
The color coat adheres better to the priming in the bottom layer, which helps to hold it in place. In order to prevent the color coat from peeling, a top coat is typically a clear coat. Both the top edge of the nails and the color coat should have it applied.
When should I put a top coat on my nails?
Unless it’s humid or a slow-drying polish, it’s usually ready for the topcoat to be applied after a minute or two. Since a fast-drying top coat is made to aid in the drying of wet polish, it’s acceptable to apply it before your polish has begun to dry.
Do you really need a top coat?
Topcoat is beneficial for your nails in terms of both look and protection from normal wear and tear. It provides an additional barrier for the nail and helps maintain the polish by avoiding chipping, fading, and dullness.
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Isabela Márquez del Sol is a contributing writer for Successible Life, covering nail trends, manicure ideas and beauty topics.